Diabetes insipidus and the use of desmopressin in hospitalised children.
نویسندگان
چکیده
There have been recent concerns raised about the hospital care of patients with diabetes insipidus and the morbidity and mortality associated with delay or omission of administration of desmopressin. This is a review of diabetes insipidus and desmopressin with a practical guide to management of these complex patients for the general paediatrician or intensive care physician caring for these children out of hours when access to specialist endocrinology may not be available.
منابع مشابه
مقایسه اثربخشی دسموپرسین خوراکی با شکل اسپری آن در درمان دیابت بیمزه مرکزی
Desmopressin(intranasal spray or drop, IV injection or tablet) is a drug choice for the treatment of central diabetes insipidus and the intranasal spray is a more common treatment. In the present study, the efficacy and side effect of oral desmopressin was compared with the intranasal spray. This before-after clinical trial study was performed on 14 outpatients(9F, 5M, age 14-50Y) w...
متن کاملDesmopressin Lyophilisate for the Treatment of Central Diabetes Insipidus: First Experience in Very Young Infants
INTRODUCTION In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. CASE PRESENTATION We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmop...
متن کاملDesmopressin for nocturnal enuresis in nephrogenic diabetes insipidus.
We have investigated two unrelated families, in which two children had inherited primary nocturnal enuresis, and nephrogenic diabetes insipidus caused by new mutations in the aquaporin-2 gene (AQP2). The mutant AQP2 proteins were inactive, suggesting that administration of desmopressin could not concentrate the urine in these patients. However, treatment with desmopressin resolved primary noctu...
متن کاملدیابت بیمزه پس از زایمان واژینال: گزارش موردی
Background: A variety of endocrine disorders can complicate pregnancy. Diabetes insipidus although uncommon, may have devastating effect on pregnancy outcome, if unrecognized and untreated. The etiology of diabetes insipidus is often unknown, many cases are likely autoimmune, with lymphocytic infiltration of the posterior pituitary gland. Massive polyuria, caused by failure of the renal tubular...
متن کاملDiabetes insipidus with impaired osmotic regulation in septo-optic dysplasia and agenesis of the corpus callosum.
The clinical and endocrinological findings in 24 children with septo-optic dysplasia and/or agenesis of the corpus callosum are described with particular reference to posterior pituitary function. Nine had diabetes insipidus. The prevalence of diabetes insipidus was similar in children with complete and incomplete forms of septo-optic dysplasia. Maintenance of normal osmotic balance was very di...
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ورودعنوان ژورنال:
- Archives of disease in childhood. Education and practice edition
دوره 102 2 شماره
صفحات -
تاریخ انتشار 2017